id: vaginal-estrogen
title: "Local vaginal estrogen"
kind: intervention
summary: >-
  Local (vaginal) estrogen is a topical estrogen therapy used for genitourinary
  symptoms of menopause. The AUA/SUFU/AUGS 2025 Guideline on Genitourinary
  Syndrome of Menopause reports that patients with recurrent urinary tract
  infections may be offered local estrogen, with moderate-level evidence
  supporting its use in reducing infection risk. Local vaginal estrogen is also
  reported elsewhere as a first-line therapy for GSM. This entry summarizes what
  the literature reports for navigation and is not medical advice.
evidence_strength: moderate
status: published
sources:
  - url: https://www.auajournals.org/doi/10.1097/JU.0000000000004589
    title: "AUA / SUFU / AUGS — 2025 Guideline on Genitourinary Syndrome of Menopause"
    publisher: American Urological Association / SUFU / AUGS (Journal of Urology)
    date: "2025"
    note: "Moderate-level evidence for reducing recurrent UTI risk."
signals:
  - sig-20260710-local-estrogen-recurrent-uti
confidence: medium
first_seen: "2026-07-10"
last_updated: "2026-07-10"
notes: >-
  Maps to entities.yml `vaginal-estrogen` (intervention). Single source
  (AUA/SUFU/AUGS 2025), so confidence is medium; the guideline itself grades
  the recurrent-UTI effect as moderate-level evidence, so evidence_strength is
  moderate. Additional guideline recommendations naming local vaginal estrogen
  as a first-line therapy for GSM are recorded on the
  `genitourinary-syndrome-menopause` symptom entry — the intervention and the
  symptom it treats are kept as distinct entries per profile.